In vivo antiulcer and in vitro antioxidant activity of Barleria gibsoni was .. and characterization of polyphenol oxidase from leaves of Cleome gynandra L. Food . Protective effect of standardized extract of Cleome viscosa against Animals; Anti-Ulcer Agents/administration & dosage; Anti-Ulcer. Research Journal of Pharmacognosy and Phytochemistry. Delivering full text access to the world’s highest quality literature.

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Capparidaceae is also known as Tickweed, or Spider plant. Mol Nutr Food Res. Role of prostaglandins in gastroprotection.

Antiulcer Herbs

High amount of flavonoids was found in EBG. After 4 h of surgery, rats were sacrificed and ulcer scoring was done. Purification and characterization of polyphenol oxidase from leaves of Cleome gynandra L.

Chemicals Ethanol, methanol, gallic acid, Folin—Ciocalteu reagent, potassium ferricyanide, trichloroacetic acid, ferric chloride, ferrous chloride, sodium nitroprusside, sulfanilamide, o-phosphoric acid, naphthylethylenediamine dihydrochloride, sodium carbonate, sodium dihydrogen phosphate dihydrate, disodium hydrogen phosphate dodecahydrate, aluminum chloride, quercetin, L-ascorbic acid, and 2,2-diphenylpicrylhydrazyl DPPHwere obtained from HiMedia Laboratory and Research Lab, India.

In pyloric ligation-induced ulcer model, oral administration of leaves in two different doses showed significant reduction in ulcer index, gastric volume, free acidity, and total acidity as compared to the control group, whereas omeprazole as reference standard drug showed a significant reduction in ulcer index, gastric volume, free acidity, and total acidity [ Table 2 ].

Eur J Clin Invest.

Evaluation of Antiulcer and Antioxidant Activity of Barleria gibsoni Dalz. Leaves

The plant derived antioxidants, especially polyphenols and flavonoids have been used to treat various disease such as cancer, diabetic, aging, and prevention of cardiovascular disease. Animal selection The experiments were carried out on Wistar strain male adult rats, aged 12—15 weeks and weighing — m. It shows the B. Nitric oxide radical scavenging activity NO radical scavenging activity of EBG was performed by the formation of NO using sodium nitroprusside.


Evaluation of anti-ulcer activity of methanolic extract of Terminalia chebula fruits in experimental rats. The ethanol extracts showed good antioxidant capacity in DPPH radical scavenging assay and NO radical scavenging activity when compared to standard.

The collected fresh matured leaves of B. Sections of tissue from stomachs were examined histopathologically to study the antiulcerogenic activity of B.

Chapman and Hall; The percentage of scavenging activity was derived using the following formula. Animals were allowed to recover and stabilize in individual cages and were deprived of water during postoperative period. The seeds and its oil have antihelminthic properties but they are ineffective in treating roundworm infections.

Oxidative stress and carcinogenesis. The results of this investigation showcase the potential antiulcer and antioxidant activities of ethanol EBG. Estimation of total phenolic content The total phenolic content of the EBG was determined using gallic acid antijlcer as described previously. The antiulccer were housed in colony cages and maintained under standard environmental conditions: The experiment was done in triplicate.

Vadlapudi V, Chandrasekhr Naidu K. Gayathri R, Anuradha V. Ligation was done without causing any damage to the blood supply of the stomach.

These findings suggest that the leaves of B. An aqueous seed extract displayed significant analgesic activity in mice and local anaesthetic activity in guinea pigs. cleoome

Measurement of gastric acidity One milliliter of the total centrifuged gastric zntiulcer from each pylorus ligated rat was analyzed for hydrogen ion concentration by titrating against 0. Antioxidants apparently protect the living system from oxidative insults, which is a hallmark feature of cancer, cardiovascular disease, and diabetes.

The standard drug ascorbic acid was used. The ability of DPPH radical scavenging was higher in the EBG even significantly lower than standard ascorbic acid thus proving strong antioxidant potential of B.


Phytochemical Screening and Anti-Ulcer Activity of Cleomo Gynandra Linn

He has more than 16 years of teaching and research experience. Peptic ulcer is a digestive disorder most commonly found in clinical practice. The gastric tissue samples were fixed in neutral buffered formalin for 24 h. A decoction is used as an expectorant and digestive stimulant and the vapour from a steaming decoction of the whole plant is inhaled to treat headache.

On pylorus ligation-accumulated secretions and the related ulcers confirm gastric acid output to be the basic cause of gastric ulcers.

Support Center Support Center. Amelioration of chronic ileitis by nitric oxide synthase inhibition. The experiments were carried out on Wistar strain male adult rats, aged 12—15 weeks and weighing — m. Reagent blank was prepared using distilled water. The parameters taken to assess antiulcer activity were volume of gastric secretion, pH, free acidity, total acidity and ulcer index.

A score for the ulcer was studied similar to pyloric ligation-induced ulcer model. Nitric oxide radical scavenging activity NO radical scavenging of EBG was carried out as previously described. It was incubated at room temperature for 30 min, the absorbance of the reaction mixture was measured at nm using ultraviolet spectrometer. The fresh leaves of the B. National Center for Biotechnology InformationU. Phytochemical screening was carried out to identify the secondary metabolites present in defatted ethanol EBG.

Research Journal of Pharmacognosy and Phytochemistry Year: It is a diffusible free radical which plays many roles as an effectors molecule in diverse biological systems including vasodilatation, antimicrobial, neuronal messenger, and antitumor activities.

AcanthaceaeBarleria gibsonigallic acid, L-ascorbic acid, pylorus ligation-induced ulcer model, quercetin.

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